De novo chiral amino alcohols in catalyzing asymmetric additions to aryl aldehydes

Org Lett. 2006 Apr 13;8(8):1565-8. doi: 10.1021/ol0600640.

Abstract

[reaction: see text] A de novo structural class of chiral amino alcohol catalysts has been identified through a synergistic effort combining novel architectures from [4 + 3] cycloadditions and quantum mechanical interaction field predictions that closely match subsequent experimental measurements.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Aldehydes / chemistry*
  • Amino Alcohols / chemistry*
  • Amino Alcohols / classification
  • Catalysis
  • Molecular Structure
  • Stereoisomerism

Substances

  • Aldehydes
  • Amino Alcohols