A number of non-organ-specific autoantibodies, such as antibodies to vimentin, centriole, the midbody of chromatin and the Golgi apparatus, were detected in the sera of patients with infectious mononucleosis or nasopharyngeal carcinoma, by using an indirect immunofluorescence technique. There was no significant correlation between the titers of anti-Epstein-Barr virus antibodies and those of autoantibodies. Our findings suggest that the autoantibody production is antigen-driven.