Heterogeneous distribution of tetrodotoxin-sensitive calcium-conducting channels in rat hippocampal CA1 neurons

N Akaike; K Takahashi; M Morimoto

doi:10.1016/0006-8993(91)90557-c

Heterogeneous distribution of tetrodotoxin-sensitive calcium-conducting channels in rat hippocampal CA1 neurons

Brain Res. 1991 Aug 9;556(1):135-8. doi: 10.1016/0006-8993(91)90557-c.

Authors

N Akaike¹, K Takahashi, M Morimoto

Affiliation

¹ Department of Neurophysiology, Tohoku University School of Medicine, Sendai, Japan.

PMID: 1657304
DOI: 10.1016/0006-8993(91)90557-c

Abstract

Voltage-dependent Ca2+ currents (ICas) in neurons can be classified into T-, N- and L-types. In the CA1 pyramidal neurons freshly isolated from rat hippocampus we found an additional tetrodotoxin (TTX)-sensitive Ca2+ current (termed 'TTX-ICa') which passed through the Na+ channel. The TTX-ICa showed a heterogeneous distribution in the dorsal site of Ca1 region.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Calcium Channels / drug effects
Calcium Channels / physiology*
Hippocampus / anatomy & histology
Hippocampus / physiology*
In Vitro Techniques
Neurons / drug effects
Neurons / physiology*
Pyramidal Tracts / physiology*
Rats
Rats, Inbred Strains
Sodium Channels / physiology
Tetrodotoxin / pharmacology*

Substances

Calcium Channels
Sodium Channels
Tetrodotoxin