Low immunologic response to highly active antiretroviral therapy in naive vertically human immunodeficiency virus type 1-infected children with severe immunodeficiency

Pediatr Infect Dis J. 2006 Apr;25(4):365-8. doi: 10.1097/01.inf.0000207419.50016.5e.

Abstract

We conducted a retrospective study to analyze the CD4 recovery of naive vertically human immunodeficiency virus-infected children with severe immunodeficiency who were followed up during at least 4 years of receiving highly active antiretroviral therapy (HAART). Children with baseline CD4 of <15% did not reach a mean CD4 of > or =25% after the 4th year on HAART. We conclude that starting HAART after severe immunosuppression of naive HIV-infected children may not be effective for recovery of normal %CD4.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Antiretroviral Therapy, Highly Active*
  • CD4-Positive T-Lymphocytes / immunology*
  • Child
  • Child, Preschool
  • Female
  • HIV Infections / complications
  • HIV Infections / drug therapy*
  • HIV Infections / immunology*
  • HIV Infections / virology
  • HIV-1
  • Humans
  • Immunologic Deficiency Syndromes / complications*
  • Infectious Disease Transmission, Vertical*
  • Male
  • Viral Load