Dense-core secretory granule biogenesis

Physiology (Bethesda). 2006 Apr:21:124-33. doi: 10.1152/physiol.00043.2005.

Abstract

The dense-core secretory granule is a key organelle for secretion of hormones and neuropeptides in endocrine cells and neurons, in response to stimulation. Cholesterol and granins are critical for the assembly of these organelles at the trans-Golgi network, and their biogenesis is regulated quantitatively by posttranscriptional and posttranslational mechanisms.

Publication types

  • Review

MeSH terms

  • Animals
  • Cholesterol / physiology
  • Chromogranins / physiology
  • Endocrine System / metabolism
  • Golgi Apparatus / physiology
  • Hormones / metabolism
  • Humans
  • Lipids / physiology
  • Neurons / metabolism
  • Neuropeptides / metabolism
  • Protein Processing, Post-Translational
  • Secretory Vesicles / chemistry*
  • Secretory Vesicles / physiology*

Substances

  • Chromogranins
  • Hormones
  • Lipids
  • Neuropeptides
  • Cholesterol