Abstract
Two studies, one in this issue of Cell and the other in Developmental Cell show that the cell-fate determinant Brain Tumor (Brat) suppresses self-renewal in one of the daughter cells that arise from the asymmetric division of a neural stem cell. This work suggests a mechanism by which loss of polarity in stem cells may lead to tumorigenesis.
MeSH terms
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Animals
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Cell Division* / genetics
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DNA-Binding Proteins / physiology
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Drosophila / embryology
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Drosophila Proteins / physiology
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Humans
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Neoplasms / etiology*
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Neoplasms / genetics
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Neoplasms / pathology*
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Nerve Tissue Proteins / physiology
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Nuclear Proteins / physiology
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Stem Cells / cytology*
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Transcription Factors / physiology
Substances
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DNA-Binding Proteins
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Drosophila Proteins
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Nerve Tissue Proteins
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Nuclear Proteins
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Transcription Factors
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brat protein, Drosophila
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pros protein, Drosophila