Enantioselective organocatalytic Michael addition reactions between N-heterocycles and nitroolefins

Jian Wang; Hao Li; Liansuo Zu; Wei Wang

doi:10.1021/ol0601794

Enantioselective organocatalytic Michael addition reactions between N-heterocycles and nitroolefins

Org Lett. 2006 Mar 30;8(7):1391-4. doi: 10.1021/ol0601794.

Authors

Jian Wang¹, Hao Li, Liansuo Zu, Wei Wang

Affiliation

¹ Department of Chemistry, University of New Mexico, Albuquerque, New Mexico 87131-0001, USA.

PMID: 16562899
DOI: 10.1021/ol0601794

Abstract

[reaction: see text] A method for Michael addition of N-heterocycles to nitroolefins has been developed. The process is promoted by a cinchona alkaloid derivative to give Michael adducts in moderate to high enantioselectivities.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Alkenes / chemistry*
Catalysis
Cinchona Alkaloids / chemistry*
Molecular Structure
Nitro Compounds / chemistry*
Stereoisomerism

Substances

Alkenes
Cinchona Alkaloids
Nitro Compounds

Grants and funding

P20 RR016480/RR/NCRR NIH HHS/United States