Cyclic semipeptoids: peptoid-organic hybrid macrocycles

Org Lett. 2006 Mar 30;8(7):1259-62. doi: 10.1021/ol052867d.

Abstract

[structure: see text] Cyclic semipeptoids 1 and 2 represent constrained, secondary structure mimics where the R(1) and R(2) side chains correspond to those of amino acids. Solid-phase syntheses and conformational analyses of these compounds are described.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Amino Acids / chemistry*
  • Models, Molecular*
  • Molecular Mimicry
  • Molecular Structure
  • Peptides, Cyclic / chemical synthesis*
  • Peptides, Cyclic / chemistry*
  • Peptoids / chemical synthesis*
  • Peptoids / chemistry*
  • Protein Conformation

Substances

  • Amino Acids
  • Peptides, Cyclic
  • Peptoids