Association of the Tau haplotype with Parkinson's disease in the Greek population

Mov Disord. 2006 Jul;21(7):1036-9. doi: 10.1002/mds.20864.

Abstract

We compared the distribution of the Tau H1 haplotype and related subhaplotypes in a group of clinically diagnosed Parkinson's disease patients (n = 133) and in control individuals (n = 113) from northern Greece. We were able to detect a statistically significant overrepresentation of the H1H1 genotype in our patient group (OR for H1H1 vs. H1H2 and H2H2: 1.73; 95% CI: 1.03-2.90; P = 0.037). The H1 subhaplotype significantly associated with the disease in our population was different from the one previously reported for a Norwegian population, suggesting that the nature of the association of Tau with Parkinson's disease is influenced by ethnic variation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Female
  • Gene Frequency / genetics
  • Genetics, Population*
  • Genotype
  • Haplotypes*
  • Humans
  • Male
  • Middle Aged
  • Parkinson Disease / diagnosis
  • Parkinson Disease / genetics*
  • Polymorphism, Genetic / genetics*
  • Reference Values
  • tau Proteins / genetics*

Substances

  • tau Proteins