Abstract
Purified maize polyamine oxidase bound to hydroxylapatite was utilized as an enzymatic reactor to produce oxidized spermidine and spermine. The oxidation products showed a consistent inhibitory activity on Leishmania infantum in mice. 1,3-diaminopropane showed a much lower activity. Moreover chemically prepared 4-aminobutyraldehyde had a similar ED50 to that of oxidized spermidine. It is concluded that among the compounds arising from polyamine oxidation those with the greatest anti-leishmanial effect are 4-aminobutyraldehyde and 1-(3-aminopropyl)-4-aminobutyraldehyde.
MeSH terms
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Aldehydes / chemical synthesis
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Aldehydes / chemistry
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Aldehydes / pharmacology*
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Animals
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Antiprotozoal Agents / chemical synthesis
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Antiprotozoal Agents / chemistry
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Antiprotozoal Agents / pharmacology*
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Catalysis
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Durapatite
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Hydroxyapatites / chemistry
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Leishmaniasis / drug therapy*
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Mice
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Mice, Inbred BALB C
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Oxidation-Reduction
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Oxidoreductases Acting on CH-NH Group Donors / chemistry*
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Polyamine Oxidase
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Spermidine / chemistry*
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Spermine / chemistry*
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Zea mays / enzymology*
Substances
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Aldehydes
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Antiprotozoal Agents
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Hydroxyapatites
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Spermine
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Durapatite
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Oxidoreductases Acting on CH-NH Group Donors
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Spermidine