Abstract
Resistin is a newly identified adipocyte secreted hormone belonging to a cysteine-rich protein family. It is expressed in white adipose tissues in rodents and has also been found in several other tissues in human. Insulin, glucose, many cytokines and anti-diabetic thiazolidinediones are regulators of resistin gene expression. Resistin was firstly proposed to be involved in insulin resistance and type 2 diabetes. Recently, it was found to be relevant to inflammation and inflammation-related diseases like atherosclerosis and arthritis.
MeSH terms
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Adipose Tissue / metabolism*
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Animals
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Arthritis / drug therapy
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Arthritis / metabolism*
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Atherosclerosis / drug therapy
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Atherosclerosis / metabolism*
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Diabetes Mellitus, Type 1 / drug therapy
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Diabetes Mellitus, Type 1 / metabolism
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Diabetes Mellitus, Type 2 / drug therapy
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Diabetes Mellitus, Type 2 / metabolism
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Gene Expression Regulation* / drug effects
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Humans
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Hypoglycemic Agents / therapeutic use
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Inflammation / drug therapy
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Inflammation / metabolism*
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Insulin Resistance
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Mice
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Rats
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Resistin / metabolism*
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Thiazolidinediones / therapeutic use
Substances
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Hypoglycemic Agents
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Resistin
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Thiazolidinediones