Pathology of supraclavicular lymphadenopathy in Chandigarh, north India: an audit of 200 cases diagnosed by needle aspiration

Cytopathology. 2006 Apr;17(2):94-6. doi: 10.1111/j.1365-2303.2006.00285.x.

Abstract

Objective: Fine needle aspiration cytology (FNAC) of lymph nodes can be used routinely as a first-line diagnostic test. The majority of studies reveal a malignant cause for palpable supraclavicular lymph nodes. The present audit further emphasizes the use of FNAC as a first-line investigation for the evaluation of enlarged supraclavicular lymph nodes.

Methods: A total of 200 cases of palpable supraclavicular lymph node(s) were included in the present study.

Results: Left supraclavicular lymph nodes were found to be more commonly involved (59.5% cases). Sixty-four per cent cases showed metastatic deposits and 13.5% cases were diagnosed as tuberculosis. Ten per cent cases showed reactive lymphoid hyperplasia; 0.5% (one) case showed only necrosis and on autopsy, a microscopic focus of choriocarcinoma was found in the testis. In 7.5% cases, diagnostic material could not be aspirated despite repeated attempts. Common metastatic tumours were from lung (22% cases), breast (16.4% cases), cervix (11% cases) and oesophagus (8.6% cases). In 13.3% cases the primary site was unknown and the diagnosis of malignancy first came from FNAC.

Conclusion: The present study further highlights the importance of FNAC as a first-line diagnostic modality in the evaluation of supraclavicular lymphadenopathy. A full history, radiological findings and immunochemistry in difficult cases can help to arrive at a definitive diagnosis.

Publication types

  • Validation Study

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Biopsy, Fine-Needle*
  • Child
  • Child, Preschool
  • Clavicle
  • Humans
  • India
  • Lymph Nodes / pathology*
  • Lymphatic Diseases / diagnosis*
  • Lymphatic Metastasis / diagnosis*
  • Middle Aged
  • Palpation
  • Predictive Value of Tests
  • Retrospective Studies
  • Sensitivity and Specificity
  • Sentinel Lymph Node Biopsy