Abstract
Steroid receptor coactivator-3 (SRC-3, also known as NCoA3, AIB1, p/CIP, RAC3, ACTR, and TRAM1), localized on a frequently amplified region, 20q12, has been associated with multiple cancers, including breast, gastric and prostate cancers. Although SRC-3 has been implicated as an oncogene, compelling evidence has only recently emerged implicating it as a causal factor in the genesis of human cancers. Here, we summarize recent evidence that indicates aberrant SRC-3 expression is important in hormone-sensitive and -insensitive human cancers.
Publication types
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Research Support, N.I.H., Extramural
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Review
MeSH terms
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Animals
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Breast Neoplasms / metabolism
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Breast Neoplasms / pathology*
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Cell Proliferation
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Cell Survival
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Histone Acetyltransferases* / chemistry
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Histone Acetyltransferases* / genetics
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Histone Acetyltransferases* / metabolism
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Humans
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Male
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Nuclear Receptor Coactivator 3
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Oncogenes*
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Prostatic Neoplasms / metabolism
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Prostatic Neoplasms / pathology
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Signal Transduction / physiology*
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Stomach Neoplasms / metabolism
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Stomach Neoplasms / pathology
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Trans-Activators* / chemistry
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Trans-Activators* / genetics
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Trans-Activators* / metabolism
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Transcription Factors* / metabolism
Substances
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Trans-Activators
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Transcription Factors
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Histone Acetyltransferases
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NCOA3 protein, human
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Nuclear Receptor Coactivator 3