Decreased striatal D1 binding as measured using PET and [11C]SCH 23,390 in patients with major depression with anger attacks

Depress Anxiety. 2006;23(3):175-7. doi: 10.1002/da.20168.

Abstract

This study assessed striatal dopamine 1 (D1) receptor binding in patients with major depressive disorder and anger attacks (MDD+A) and healthy volunteers. We used positron emission tomography with [(11)C]SCH 23,390 to compare 10 patients with MDD+A to 10 healthy volunteers. [(11)C]SCH 23,390 binding in bilateral striata was significantly lower in the MDD+A group when compared to healthy volunteers. These results implicate striatal D1 receptor dysfunction in MDD+A and further suggest an association between dopaminergic transmission and anger or aggression.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Adult
  • Aggression / physiology
  • Anger / physiology*
  • Benzazepines / pharmacokinetics*
  • Carbon Radioisotopes / pharmacokinetics
  • Corpus Striatum / diagnostic imaging*
  • Depressive Disorder, Major / diagnostic imaging
  • Dominance, Cerebral / physiology
  • Dopamine / metabolism
  • Female
  • Humans
  • Male
  • Middle Aged
  • Positron-Emission Tomography*
  • Receptors, Dopamine D1 / metabolism*
  • Reference Values

Substances

  • Benzazepines
  • Carbon Radioisotopes
  • Receptors, Dopamine D1
  • Dopamine