Pharmacological-induced haptic changes and the accommodative performance in patients with the AT-45 accommodative IOL

J Refract Surg. 2006 Feb;22(2):145-50. doi: 10.3928/1081-597X-20060201-11.

Abstract

Purpose: To investigate the accommodative performance of the AT-45 (eyeonics Inc, Aliso Viejo, Calif) using three-dimensional ultrasound biomicroscopy.

Methods: The AT-45 haptic region was visualized in vivo 1 month after surgery in four patients using an in-house developed three-dimensional ultrasound biomicroscope. Haptic changes, axial shift, and accommodation amplitude were determined under pharmacologically induced accommodation.

Results: The angulation, depending on the accommodation state, could be distinguished and analyzed. In vivo a mean change in haptic angulation of 3.3 +/- 3.3 degrees (range: 0 degrees to 7 degrees) and a mean forward shift of 0.13 +/- 0.08 mm (range: 0.05 to 0.2 mm) were observed for the AT-45 using pharmacologically induced accommodation. A mean accommodative amplitude of 0.44 +/- 0.24 diopters (D) (range: 0.25 to 0.75 D) was found using a Hartinger coincidence refractometer.

Conclusions: Minimal angulation changes and axial movements of the AT-45 have been demonstrated using pharmacological stimulation and objective measurement methods. The mechanical performance of the AT-45 in these eyes does not appear to provide the range of accommodation necessary for close work.

Publication types

  • Comparative Study

MeSH terms

  • Accommodation, Ocular / drug effects*
  • Accommodation, Ocular / physiology
  • Aged
  • Cyclopentolate / administration & dosage
  • Female
  • Follow-Up Studies
  • Humans
  • Lenses, Intraocular*
  • Microscopy, Acoustic
  • Middle Aged
  • Miotics / administration & dosage*
  • Mydriatics / administration & dosage*
  • Ophthalmic Solutions
  • Pilocarpine / administration & dosage
  • Prosthesis Design
  • Pseudophakia / diagnostic imaging
  • Pseudophakia / physiopathology*
  • Refraction, Ocular / drug effects
  • Refraction, Ocular / physiology

Substances

  • Miotics
  • Mydriatics
  • Ophthalmic Solutions
  • Pilocarpine
  • Cyclopentolate