The ASK1-MAP kinase pathways in immune and stress responses

Teruyuki Hayakawa; Atsushi Matsuzawa; Takuya Noguchi; Kohsuke Takeda; Hidenori Ichijo

doi:10.1016/j.micinf.2005.12.001

The ASK1-MAP kinase pathways in immune and stress responses

Microbes Infect. 2006 Apr;8(4):1098-107. doi: 10.1016/j.micinf.2005.12.001. Epub 2006 Jan 19.

Authors

Teruyuki Hayakawa¹, Atsushi Matsuzawa, Takuya Noguchi, Kohsuke Takeda, Hidenori Ichijo

Affiliation

¹ Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.

PMID: 16517200
DOI: 10.1016/j.micinf.2005.12.001

Abstract

Apoptosis signal-regulating kinase 1 (ASK1) is a mitogen-activated protein kinase kinase kinase which plays pivotal roles in stress and immune responses. This review is focused on three major subjects on ASK1: the regulatory mechanisms of the kinase activity, the pathophysiological roles in stress response and innate immunity, and the evolutionary perspectives.

Publication types

Review

MeSH terms

Animals
Caenorhabditis elegans / immunology
Caenorhabditis elegans / metabolism
Drosophila / immunology
Drosophila / metabolism
Humans
Immunity, Innate
Inflammation / metabolism
MAP Kinase Kinase Kinase 5 / chemistry
MAP Kinase Kinase Kinase 5 / metabolism*
MAP Kinase Signaling System / immunology
MAP Kinase Signaling System / physiology*
Stress, Physiological / immunology
Stress, Physiological / physiopathology*
Toll-Like Receptors / metabolism

Substances

Toll-Like Receptors
MAP Kinase Kinase Kinase 5