Abstract
A simple and highly sensitive spectrophotometric method for the determination of anthracycline anticancer agents, such as Daunorubicin hydrochloride (DAU), was established by using aluminum(III) and Chromazurol S (CAS) in a nonionic surfactant micellar medium. In the case of determination of DAU, the apparent molar absorptivity was 1.3 x 10(5) dm3 mol(-1) cm(-1) at 615 nm. Beer's law was obeyed in the concentration range of 0.028 - 2.82 microg ml(-1) for DAU. Owing to no need for solvent extraction, this method could be applied to assays of DAU and related drugs in pharmaceutical preparations.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Aluminum / chemistry*
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Anthracyclines / chemistry*
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Antibiotics, Antineoplastic / chemistry*
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / pharmacology
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Calibration
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Chemistry Techniques, Analytical / methods*
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Chemistry, Pharmaceutical / methods
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Coloring Agents / pharmacology
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Hydrogen-Ion Concentration
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Hydroxybenzoates / chemistry*
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Ions
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Micelles*
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Regression Analysis
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Spectrophotometry
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Surface-Active Agents / chemistry
Substances
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Anthracyclines
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Antibiotics, Antineoplastic
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Antineoplastic Agents
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Coloring Agents
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Hydroxybenzoates
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Ions
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Micelles
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Surface-Active Agents
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chrome azurol S
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Aluminum