Spectrophotometric determination of anthracycline anticancer agents with aluminum(III) and chromazurol S in a nonionic surfactant micellar medium

Anal Sci. 2006 Feb;22(2):313-6. doi: 10.2116/analsci.22.313.

Abstract

A simple and highly sensitive spectrophotometric method for the determination of anthracycline anticancer agents, such as Daunorubicin hydrochloride (DAU), was established by using aluminum(III) and Chromazurol S (CAS) in a nonionic surfactant micellar medium. In the case of determination of DAU, the apparent molar absorptivity was 1.3 x 10(5) dm3 mol(-1) cm(-1) at 615 nm. Beer's law was obeyed in the concentration range of 0.028 - 2.82 microg ml(-1) for DAU. Owing to no need for solvent extraction, this method could be applied to assays of DAU and related drugs in pharmaceutical preparations.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aluminum / chemistry*
  • Anthracyclines / chemistry*
  • Antibiotics, Antineoplastic / chemistry*
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / pharmacology
  • Calibration
  • Chemistry Techniques, Analytical / methods*
  • Chemistry, Pharmaceutical / methods
  • Coloring Agents / pharmacology
  • Hydrogen-Ion Concentration
  • Hydroxybenzoates / chemistry*
  • Ions
  • Micelles*
  • Regression Analysis
  • Spectrophotometry
  • Surface-Active Agents / chemistry

Substances

  • Anthracyclines
  • Antibiotics, Antineoplastic
  • Antineoplastic Agents
  • Coloring Agents
  • Hydroxybenzoates
  • Ions
  • Micelles
  • Surface-Active Agents
  • chrome azurol S
  • Aluminum