Highly enantioselective hydrovinylation of alpha-alkyl vinylarenes. an approach to the construction of all-carbon quaternary stereocenters

Wen-Jian Shi; Qi Zhang; Jian-Hua Xie; Shou-Fei Zhu; Guo-Hua Hou; Qi-Lin Zhou

doi:10.1021/ja057654y

Highly enantioselective hydrovinylation of alpha-alkyl vinylarenes. an approach to the construction of all-carbon quaternary stereocenters

J Am Chem Soc. 2006 Mar 8;128(9):2780-1. doi: 10.1021/ja057654y.

Authors

Wen-Jian Shi¹, Qi Zhang, Jian-Hua Xie, Shou-Fei Zhu, Guo-Hua Hou, Qi-Lin Zhou

Affiliation

¹ State Key Laboratory and Institute of Elemento-organic Chemistry, Nankai University, Tianjin 300071, China.

PMID: 16506739
DOI: 10.1021/ja057654y

Abstract

The highly enantioselective hydrovinylation of alpha-alkyl vinylarenes was realized by using nickel complexes of chiral spiro phosphoramidite ligands. The method provided a new approach to the construction of chiral all-carbon quaternary centers.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Hydrocarbons, Aromatic / chemical synthesis*
Hydrocarbons, Aromatic / chemistry
Organophosphorus Compounds / chemistry
Stereoisomerism
Vinyl Compounds / chemical synthesis*
Vinyl Compounds / chemistry

Substances

Hydrocarbons, Aromatic
Organophosphorus Compounds
Vinyl Compounds
phosphoramidite