Antibacterial galloylated alkylphloroglucinol glucosides from myrtle (Myrtus communis)

Giovanni Appendino; Lucia Maxia; Piergiorgio Bettoni; Monica Locatelli; Carola Valdivia; Mauro Ballero; Michael Stavri; Simon Gibbons; Olov Sterner

doi:10.1021/np050462w

Antibacterial galloylated alkylphloroglucinol glucosides from myrtle (Myrtus communis)

J Nat Prod. 2006 Feb;69(2):251-4. doi: 10.1021/np050462w.

Authors

Giovanni Appendino¹, Lucia Maxia, Piergiorgio Bettoni, Monica Locatelli, Carola Valdivia, Mauro Ballero, Michael Stavri, Simon Gibbons, Olov Sterner

Affiliation

¹ Dipartimento di Scienze Chimiche, Alimentari, Farmaceutiche e Farmacologiche, Università del Piemonte Orientale, Viale Ferrucci 33, 28100 Novara, Italy. appendino@pharm.unipmn.it

PMID: 16499325
DOI: 10.1021/np050462w

Abstract

An investigation of the polar glycosidic fraction from the leaves of myrtle afforded four galloylated nonprenylated phloroglucinol glucosides (3a-d) related to the endoperoxide hormone G3 (4) in terms of structure and biogenesis. Despite their close similarity, significant antibacterial activity was shown only by one of these compounds (3b, gallomyrtucommulone B), while the G3 hormone (4) was inactive.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Anti-Bacterial Agents
Glucosides / chemistry
Glucosides / isolation & purification*
Glucosides / pharmacology*
Microbial Sensitivity Tests
Molecular Structure
Myrtus / chemistry*
Phloroglucinol* / analogs & derivatives
Phloroglucinol* / chemistry
Phloroglucinol* / isolation & purification
Phloroglucinol* / pharmacology
Plant Leaves / chemistry
Staphylococcus aureus / drug effects

Substances

Anti-Bacterial Agents
Glucosides
Phloroglucinol