Potent in vitro synergism of fluconazole and berberine chloride against clinical isolates of Candida albicans resistant to fluconazole

Hua Quan; Ying-Ying Cao; Zheng Xu; Jing-Xia Zhao; Ping-Hui Gao; Xiao-Feng Qin; Yuan-Ying Jiang

doi:10.1128/AAC.50.3.1096-1099.2006

Potent in vitro synergism of fluconazole and berberine chloride against clinical isolates of Candida albicans resistant to fluconazole

Antimicrob Agents Chemother. 2006 Mar;50(3):1096-9. doi: 10.1128/AAC.50.3.1096-1099.2006.

Authors

Hua Quan¹, Ying-Ying Cao, Zheng Xu, Jing-Xia Zhao, Ping-Hui Gao, Xiao-Feng Qin, Yuan-Ying Jiang

Affiliation

¹ Department of Pharmacology, School of Pharmacy, Second Military Medical University, Shanghai, People's Republic of China.

Abstract

In vitro interaction of fluconazole and berberine chloride was investigated against 40 fluconazole-resistant clinical isolates of Candida albicans. Synergism in fungistatic activity was found with the checkerboard microdilution assay. The findings of agar diffusion tests and time-kill curves confirmed the synergistic interaction, but no antagonistic action was observed.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antifungal Agents / pharmacology*
Berberine / pharmacology*
Candida albicans / drug effects
Candida albicans / genetics*
Candida albicans / isolation & purification
Candidiasis / drug therapy
Candidiasis / microbiology
Drug Resistance, Fungal / drug effects
Drug Resistance, Fungal / genetics*
Drug Synergism
Fluconazole / pharmacology*
Humans
In Vitro Techniques
Microbial Sensitivity Tests

Substances

Antifungal Agents
Berberine
Fluconazole