The treatment of the simulated lead-contaminated solid waste by composting with white-rot fungus was studied at laboratory scale. The composting system without the inocula of white-rot fungus was prepared as control, and the composting of the uncontaminated solid waste with the inocula of white-rot fungus was carried out as the other control. The results indicated that the solid waste inoculated with white-rot fungus could be successfully processed. The final compost was mature with 70.5% of lead (Pb) in residual fraction and none in exchangeable fraction. Germination index reached 120%. All the results indicated that the bioavailability of Pb in compost was reduced and the potential harm of Pb in compost was alleviated by composting with the inocula of white-rot fungus.