Evaluation of a direct, rapid immunohistochemical test for rabies diagnosis

Emerg Infect Dis. 2006 Feb;12(2):310-3. doi: 10.3201/eid1202.050812.

Abstract

A direct rapid immunohistochemical test (dRIT) was evaluated under field and laboratory conditions to detect rabies virus antigen in frozen and glycerol-preserved field brain samples from northwestern Tanzania. Compared to the direct fluorescent antibody test, the traditional standard in rabies diagnosis, the dRIT was 100% sensitive and specific.

Publication types

  • Comparative Study
  • Evaluation Study
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Animals, Domestic / virology*
  • Animals, Wild / virology*
  • Antigens, Viral / analysis*
  • Brain / virology
  • Cats
  • Cattle
  • Dogs
  • Glycerol
  • Immunohistochemistry / methods*
  • Population Surveillance
  • Rabies / diagnosis
  • Rabies / epidemiology
  • Rabies / veterinary*
  • Rabies / virology
  • Rabies virus / isolation & purification*
  • Sensitivity and Specificity
  • Tanzania / epidemiology
  • Time Factors
  • Tissue Preservation

Substances

  • Antigens, Viral
  • Glycerol