Abstract
Is there a cellular mechanism for preventing a depolymerizing microtubule track from "slipping out from under" its cargo? A recent study in budding yeast indicates that when a chromosome is transported to the minus end of a spindle microtubule, its kinetochore-bound microtubule plus end-tracking protein (+TIP) Stu2 may move to the plus end to promote rescue; i.e., to switch the depolymerizing end to a polymerizing end. The possibility that other +TIPs may play a similar role in sustaining a microtubule track during vesicular transport deserves investigation.
Publication types
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Research Support, N.I.H., Extramural
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Review
MeSH terms
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Animals
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Biological Transport, Active / physiology
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Microtubule Proteins / metabolism
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Microtubule Proteins / physiology*
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Microtubule-Associated Proteins / metabolism
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Microtubule-Associated Proteins / physiology
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Molecular Motor Proteins / metabolism
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Molecular Motor Proteins / physiology*
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Neoplasm Proteins / metabolism
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Neoplasm Proteins / physiology
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Saccharomyces cerevisiae Proteins / metabolism
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Saccharomyces cerevisiae Proteins / physiology
Substances
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Microtubule Proteins
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Microtubule-Associated Proteins
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Molecular Motor Proteins
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Neoplasm Proteins
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STU2 protein, S cerevisiae
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Saccharomyces cerevisiae Proteins
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cytoplasmic linker protein 170