Abstract
Three new free radical scavengers were isolated from the methanolic extract of the fruiting bodies of Inonotus xeranticus (Hymenochaetaceae), along with the known compound davallialactone. Their structures were established as hispidin analogs by extensive NMR spectral data. Compounds 3 and 4 displayed significant scavenging activity against the superoxide radical anion, ABTS radical cation, and DPPH radical, while 1 and 2 exhibited potent antioxidative activity only against ABTS radical cation.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Agaricales / chemistry*
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Anions / chemistry
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Antioxidants / chemistry*
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Antioxidants / isolation & purification
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Antioxidants / pharmacology*
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Benzothiazoles
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Biphenyl Compounds
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Cations / chemistry
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Free Radical Scavengers / chemistry*
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Free Radical Scavengers / isolation & purification
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Free Radical Scavengers / pharmacology*
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Free Radicals / antagonists & inhibitors
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Free Radicals / chemistry
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Magnetic Resonance Spectroscopy / methods
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Magnetic Resonance Spectroscopy / standards
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Molecular Structure
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Picrates / antagonists & inhibitors
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Picrates / chemistry
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Pyrones / chemistry*
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Pyrones / isolation & purification
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Reference Standards
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Stereoisomerism
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Sulfonic Acids / antagonists & inhibitors
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Sulfonic Acids / chemistry
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Superoxides / antagonists & inhibitors
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Superoxides / chemistry
Substances
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Anions
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Antioxidants
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Benzothiazoles
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Biphenyl Compounds
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Cations
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Free Radical Scavengers
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Free Radicals
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Picrates
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Pyrones
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Sulfonic Acids
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Superoxides
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2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid
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1,1-diphenyl-2-picrylhydrazyl
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hispidin