Hydrogen sulphide--a novel mediator of inflammation?

Ling Li; Madhav Bhatia; Philip K Moore

doi:10.1016/j.coph.2005.10.007

Hydrogen sulphide--a novel mediator of inflammation?

Curr Opin Pharmacol. 2006 Apr;6(2):125-9. doi: 10.1016/j.coph.2005.10.007. Epub 2006 Feb 17.

Authors

Ling Li¹, Madhav Bhatia, Philip K Moore

Affiliation

¹ Cardiovascular Biology Research Group, Department of Pharmacology, Yong Loo Lin School of Medicine, Block MD2, 18 Medical Drive, National University of Singapore, Singapore 117597.

PMID: 16487749
DOI: 10.1016/j.coph.2005.10.007

Abstract

Hydrogen sulphide (H2S) is a naturally occurring gas synthesized from cysteine. It exhibits vasodilator activity (most probably by opening vascular smooth muscle K(ATP) channels), influences leucocyte chemotaxis and promotes vascular smooth muscle cell apoptosis. Increased biosynthesis of H2S has been demonstrated in animal models of septic/endotoxic and haemorrhagic shock, pancreatitis and carrageenan-evoked hindpaw oedema in the rat. In each case, pharmacological inhibition of H2S biosynthesis is anti-inflammatory.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Disease Models, Animal*
Humans
Hydrogen Sulfide* / adverse effects
Hydrogen Sulfide* / pharmacology
Hydrogen Sulfide* / therapeutic use
Inflammation / drug therapy*
Vasodilator Agents / pharmacology*

Substances

Vasodilator Agents
Hydrogen Sulfide