Land-use planning (LUP) with respect to major accident hazards is one of the more important requirements of Directive 96/82/EC (the so-called Seveso II Directive). Different approaches were developed by the Member States of the European Union in order to implement this aspect of the Directive. This study focuses on the comparison of the specific approaches developed for LUP with respect to major accidents hazards. An Italian industrial area has been selected to perform a case study. The different LUP criteria have been used both to evaluate the present state of the area and the effect of several proposed hazard reduction actions. The results obtained have allowed a comparison of the different LUP methodologies. Critical steps in the application of the different LUP criteria have been identified, and the different priorities of hazard reduction actions resulting from risk-based and consequence-based approaches have been highlighted.