Core percolation and onset of complexity in boolean networks

Phys Rev Lett. 2006 Jan 13;96(1):018101. doi: 10.1103/PhysRevLett.96.018101. Epub 2006 Jan 4.

Abstract

The determination and classification of fixed points of large Boolean networks is addressed in terms of a constraint-satisfaction problem. We develop a general simplification scheme that, removing all those variables and functions belonging to trivial logical cascades, returns the computational core of the network. The transition line from an easy to a complex regulatory phase is described as a function of the parameters of the model, identifying thereby both theoretically and algorithmically the relevant regulatory variables.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Algorithms*
  • Gene Expression Regulation*
  • Models, Genetic*