CCR5delta32, CCR2-64I, and SDF1-3'A polymorphisms related to resistance to HIV-1 infection and disease in the Ecuadorian population

Hum Biol. 2005 Aug;77(4):521-6. doi: 10.1353/hub.2005.0068.

Abstract

The aim of this study was to determine the allele frequencies of genetic variants CCR5delta32, CCR2-64I, and SDF1-3'A (SDF1 801 A), which influence susceptibility to HIV-1 infection. We also investigated the effect of these variants on the general Ecuadoran population and on a group of HIV-infected individuals to determine the frequency of these genetics variants.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Alleles
  • Chemokine CXCL12
  • Chemokines, CXC / genetics*
  • Chi-Square Distribution
  • Child
  • Child, Preschool
  • Ecuador
  • Female
  • Gene Frequency
  • Genetic Predisposition to Disease
  • Genetics, Population
  • Genotype
  • HIV Infections / genetics*
  • HIV-1*
  • Humans
  • Infant
  • Male
  • Middle Aged
  • Polymorphism, Genetic*
  • Receptors, CCR2
  • Receptors, CCR5 / genetics*
  • Receptors, Chemokine / genetics*

Substances

  • CCR2 protein, human
  • CXCL12 protein, human
  • Chemokine CXCL12
  • Chemokines, CXC
  • Receptors, CCR2
  • Receptors, CCR5
  • Receptors, Chemokine