Abstract
Rickettsia typhi causes endemic typhus, a relatively mild, acute febrile illness characterized by headache and macular rash. It is maintained in rodents and transmitted to humans by flea Xenopsylla cheopis. R. typhi contains a lipopolysaccharide thought to display a noticeable antigenic activity. We examined its structural features and it appears that the O-specific chain of the R. typhi LPS is composed mainly of the alternating Glc and QuiNAc residues linked by 1-->4 bonds.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Carbohydrate Conformation
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Carbohydrate Sequence
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Electrophoresis, Polyacrylamide Gel
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Gas Chromatography-Mass Spectrometry
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Humans
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Lipopolysaccharides / chemistry*
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Lipopolysaccharides / isolation & purification
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Lipopolysaccharides / toxicity
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Rickettsia typhi / chemistry*
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Rickettsia typhi / immunology*
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Spectrometry, Mass, Electrospray Ionization
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Typhus, Endemic Flea-Borne / metabolism
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Typhus, Endemic Flea-Borne / microbiology*