Disseminate and fatal cytomegalovirus disease with thymitis in a naive HIV-patient after early initiation of HAART: immune restoration disease?

J Clin Virol. 2006 May;36(1):13-6. doi: 10.1016/j.jcv.2005.12.007. Epub 2006 Feb 14.

Abstract

We describe a naive HIV-infected patient who developed a Pneumocystis carinii pneumonia and disseminate and fatal cytomegalovirus disease within 3 months after initiation of HAART, suggesting due to coincidence in time, an immune restoration disease. We propose an alternative hypothesis.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • AIDS-Related Opportunistic Infections / immunology*
  • AIDS-Related Opportunistic Infections / virology
  • Adult
  • Antiretroviral Therapy, Highly Active*
  • CD4 Lymphocyte Count
  • Cytomegalovirus Infections / complications*
  • Fatal Outcome
  • Female
  • HIV Infections / complications*
  • HIV Infections / drug therapy*
  • Humans
  • Immunohistochemistry
  • Inclusion Bodies, Viral / metabolism
  • Lung / virology
  • Mediastinum / diagnostic imaging
  • Meningoencephalitis / pathology
  • Pneumonia, Pneumocystis / immunology*
  • RNA, Viral / blood
  • Radiography
  • Receptors, Antigen, T-Cell / analysis
  • Thymus Gland / virology
  • Time Factors
  • Viral Load

Substances

  • RNA, Viral
  • Receptors, Antigen, T-Cell