Temple Health Connection exemplifies the education, research, and service missions of the university through the provision of culturally competent and effective primary health care. This article reports on the history and successes of a community-based, community-driven academic nursing center at Temple University in Philadelphia, Pennsylvania. Pender's Health Promotion Model has been used to guide the design of interventions, and theoretical propositions are related to community programs and projects. Demographic characteristics of the population served and statistics on both primary care and community outreach efforts are presented. Collaborative efforts are framed in terms of successful funding and programming initiatives.