A chemo-enzymatic route to enantiomerically pure cyclic tertiary amines

J Am Chem Soc. 2006 Feb 22;128(7):2224-5. doi: 10.1021/ja058536d.

Abstract

Deracemization of racemic chiral tertiary amines has been achieved by combination of an enantioselective amine oxidase, obtained through directed evolution, and ammonia borane in a one-pot process.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amination
  • Amines / chemical synthesis*
  • Aspergillus niger / enzymology
  • Monoamine Oxidase / chemistry*
  • Monoamine Oxidase / metabolism
  • Stereoisomerism

Substances

  • Amines
  • Monoamine Oxidase