Histamine H2-receptor in atrium: signal transduction and response

Agents Actions Suppl. 1991:33:295-300. doi: 10.1007/978-3-0348-7309-3_21.

Abstract

We have examined the signal transduction for H2-receptor mediated positive chronotropic response of guinea-pig right atrium. Our results indicate that phospholipid methylation is rapidly induced by histamine acting on H2-receptor in guinea-pig right atrium and therefore plays a predominant role in the signal transfer of H2-receptor-mediated cyclic AMP generation to exert positive chronotropic effect of atrium, as well as GTP-binding protein activation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenylyl Cyclases / metabolism
  • Animals
  • Cyclic AMP / biosynthesis
  • GTP-Binding Proteins / physiology
  • Guanosine Triphosphate / pharmacology
  • Guinea Pigs
  • Heart Atria / drug effects
  • Heart Atria / metabolism
  • Heart Rate / drug effects
  • Histamine / pharmacology
  • Homocysteine / pharmacology
  • Methylation
  • Myocardium / metabolism*
  • Phospholipids / metabolism
  • Receptors, Histamine H2 / metabolism*
  • Signal Transduction*
  • Stimulation, Chemical

Substances

  • Phospholipids
  • Receptors, Histamine H2
  • Homocysteine
  • Histamine
  • Guanosine Triphosphate
  • Cyclic AMP
  • GTP-Binding Proteins
  • Adenylyl Cyclases