Abstract
We have examined the signal transduction for H2-receptor mediated positive chronotropic response of guinea-pig right atrium. Our results indicate that phospholipid methylation is rapidly induced by histamine acting on H2-receptor in guinea-pig right atrium and therefore plays a predominant role in the signal transfer of H2-receptor-mediated cyclic AMP generation to exert positive chronotropic effect of atrium, as well as GTP-binding protein activation.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adenylyl Cyclases / metabolism
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Animals
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Cyclic AMP / biosynthesis
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GTP-Binding Proteins / physiology
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Guanosine Triphosphate / pharmacology
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Guinea Pigs
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Heart Atria / drug effects
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Heart Atria / metabolism
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Heart Rate / drug effects
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Histamine / pharmacology
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Homocysteine / pharmacology
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Methylation
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Myocardium / metabolism*
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Phospholipids / metabolism
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Receptors, Histamine H2 / metabolism*
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Signal Transduction*
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Stimulation, Chemical
Substances
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Phospholipids
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Receptors, Histamine H2
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Homocysteine
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Histamine
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Guanosine Triphosphate
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Cyclic AMP
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GTP-Binding Proteins
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Adenylyl Cyclases