Abstract
Leuprorelin acetate, a chemotherapeutic agent used to treat prostate cancer, is a synthetic luteinizing hormone-releasing hormone (LHRH) agonist. We report a 75-year-old man who presented with several large subcutaneous nodules at the site of leuprorelin acetate injections for his prostatic cancer. A biopsy of the nodules disclosed epithelioid granulomatous inflammation and resulted in a diagnosis of drug-induced granulomatous reaction to leuprorelin acetate.
MeSH terms
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Abdomen
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Aged
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Antineoplastic Agents, Hormonal / administration & dosage
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Antineoplastic Agents, Hormonal / adverse effects*
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Diagnosis, Differential
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Gonadotropin-Releasing Hormone / agonists*
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Granuloma / chemically induced
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Granuloma / diagnosis*
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Granuloma / pathology
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Humans
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Injections, Subcutaneous
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Leuprolide / administration & dosage
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Leuprolide / adverse effects*
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Male
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Prostatic Neoplasms / drug therapy
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Skin Neoplasms / chemically induced
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Skin Neoplasms / diagnosis*
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Skin Neoplasms / pathology
Substances
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Antineoplastic Agents, Hormonal
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Gonadotropin-Releasing Hormone
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Leuprolide