Granulomas induced by subcutaneous injection of leuprorelin acetate

J Dermatol. 2006 Jan;33(1):43-5. doi: 10.1111/j.1346-8138.2006.00008.x.

Abstract

Leuprorelin acetate, a chemotherapeutic agent used to treat prostate cancer, is a synthetic luteinizing hormone-releasing hormone (LHRH) agonist. We report a 75-year-old man who presented with several large subcutaneous nodules at the site of leuprorelin acetate injections for his prostatic cancer. A biopsy of the nodules disclosed epithelioid granulomatous inflammation and resulted in a diagnosis of drug-induced granulomatous reaction to leuprorelin acetate.

Publication types

  • Case Reports

MeSH terms

  • Abdomen
  • Aged
  • Antineoplastic Agents, Hormonal / administration & dosage
  • Antineoplastic Agents, Hormonal / adverse effects*
  • Diagnosis, Differential
  • Gonadotropin-Releasing Hormone / agonists*
  • Granuloma / chemically induced
  • Granuloma / diagnosis*
  • Granuloma / pathology
  • Humans
  • Injections, Subcutaneous
  • Leuprolide / administration & dosage
  • Leuprolide / adverse effects*
  • Male
  • Prostatic Neoplasms / drug therapy
  • Skin Neoplasms / chemically induced
  • Skin Neoplasms / diagnosis*
  • Skin Neoplasms / pathology

Substances

  • Antineoplastic Agents, Hormonal
  • Gonadotropin-Releasing Hormone
  • Leuprolide