Efficient and green telescoped process to 2-methoxy-3-methyl-[1,4]benzoquinone

J Org Chem. 2006 Feb 17;71(4):1703-6. doi: 10.1021/jo0522512.

Abstract

A telescoped process for the preparation of 2-methoxy-3-methyl-[1,4]benzoquinone is disclosed. When this novel process is compared to the prevailing method that utilizes Na2Cr2O7 as the oxidant, the novel process represents a high yielding (95%), green, and environmentally benign alternative with H2O2 and HNO3 as the oxidants and CH3COOH as the reaction medium.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetic Acid / chemistry
  • Benzoquinones / chemical synthesis*
  • Environmental Pollution / prevention & control*
  • Hydrogen Peroxide / chemistry
  • Oxidants / chemistry

Substances

  • 2-methoxy-3-methyl-1,4-benzoquinone
  • Benzoquinones
  • Oxidants
  • Hydrogen Peroxide
  • Acetic Acid