Environmentally mediated systemic involvement of autoimmunity, allergy and carcinogenesis are very common by clinical and epidemiological investigation. However, there is an unknown relationship between environment and environmentally mediated systemic involvement of autoimmunity, allergy and carcinogenesis. This unknown molecular communication or response conducts the primary injury sites of the skin, and surface mucosa in the respiratory, alimentary, or reproductive tracts, to the secondary sites or even the whole body under some physiological and pathological conditions. Also, this unknown molecular communication or response involves a variety of molecular events, detectable in systemic differentiation, overexpression, hyperplasia, carcinogenesis, allergies or autoimmunity. The family members of proteins and their relatives are almost ubiquitous, and distribution is tightly regulated at all three administrative levels to form an interacting multiprotein complex. The key question is whether there is unknown communication or response among the family members and, if there is, is it associated with some social property of the proteins in the open body system?