Objective: To investigate the outcome of xenogeneic (porcine) acellular dermal matrix in vivo.
Methods: Xenogeneic (porcine) acellular dermal matrix was prepared by removing cellular components with trypsin and triton X-100 and was embedded under the skin of SD rat. Gross and histological changes were observed periodically.
Results: There was no cellular components but with intact basal membrane, and collagen was found to have a regular arrangement in xenogeneic (porcine) acellular dermal matrix. Grossly, the xenogeneic (porcine) acellular dermal matrix was found to disintegrate gradually. Histological examination revealed that xenogeneic (porcine) acellular dermal matrix was mainly infiltrated by inflammatory cells in one week after implantation. After one week, fibroblasts and capillary vessel increased in number gradually, and collagen began to arrange densely in regular manner.
Conclusion: Xenogeneic (porcine) acellular dermal matrix disintegrates gradually after transplantation, inducing growth of fibroblasts and capillaries.