Larvicidal, antimycobacterial and antifungal compounds from the bark of the Peruvian plant Swartzia polyphylla DC

Rosario Rojas; Betty Bustamante; Palmira Ventosilla; Irma Fernádez; Luz Caviedes; Robert Henry Gilman; Olga Lock; Gerald Bruce Hammond

doi:10.1248/cpb.54.278

Larvicidal, antimycobacterial and antifungal compounds from the bark of the Peruvian plant Swartzia polyphylla DC

Chem Pharm Bull (Tokyo). 2006 Feb;54(2):278-9. doi: 10.1248/cpb.54.278.

Authors

Rosario Rojas¹, Betty Bustamante, Palmira Ventosilla, Irma Fernádez, Luz Caviedes, Robert Henry Gilman, Olga Lock, Gerald Bruce Hammond

Affiliation

¹ Departamento de Ciencias Farmacéuticas, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia, Lima, Peru.

PMID: 16462085
DOI: 10.1248/cpb.54.278

Abstract

The 95% ethanol extract of the bark of Swartzia polyphylla DC (Fabaceae) possesses important larvicidal, antimycobacterial and antifungal activity in vitro. Bioassay-guided studies performed on the crude ethanol extract afforded T-cadinol as the larvicidal and anti-Mycobacterium tuberculosis principle, while the antifungal activity of the extract is due to the presence of the flavonoids biochanin A and dihydrobiochanin A.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antifungal Agents / chemistry*
Antifungal Agents / pharmacology*
Antitubercular Agents / chemistry*
Antitubercular Agents / pharmacology*
Biological Assay
Culex
Drug Evaluation, Preclinical
Fabaceae / chemistry*
Insecticides / chemistry*
Insecticides / pharmacology*
Larva / drug effects
Magnetic Resonance Spectroscopy
Mass Spectrometry
Microbial Sensitivity Tests
Mycobacterium tuberculosis / drug effects
Peru
Trichophyton / drug effects

Substances

Antifungal Agents
Antitubercular Agents
Insecticides