Abstract
The title compound, C30H34FNO7S, is a key intermediate in the design of dual 5-LOX (5-lipoxygenase)/COX-2 (cyclooxygenase-2) inhibitors. The compound crystallizes as a racemate. Linear hydrogen-bonded chains are aligned along the [201] direction, and stacked pi-pi interactions and C-H...O contacts stabilize the crystal structure.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Crystallography, X-Ray
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Cyclooxygenase Inhibitors / chemistry*
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Cyclooxygenase Inhibitors / pharmacology
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Hydrogen Bonding
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Lipoxygenase Inhibitors / chemistry*
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Lipoxygenase Inhibitors / pharmacology
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Models, Molecular
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Molecular Structure
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Morpholines / chemistry*
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Sulfinic Acids / chemistry*
Substances
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(2RS,5SR,6SR)-methyl 4-(cis-2-(3-fluoro-5-(4-methoxy-3,4,5,6-tetrahydro-2H-pyran-4-yl)phenoxymethyl)-6-hydroxy-3-phenylmorpholino)benzenesulfinate
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Cyclooxygenase Inhibitors
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Lipoxygenase Inhibitors
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Morpholines
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Sulfinic Acids