Abstract
We examined the quinolone resistance-determining region (QRDR) of gyrA, gyrB, and parC of recently isolated fluoroquinolone-resistant S. dysenteriae type 1 strains from south Asia and compared data with fluoroquinolone-susceptible strains associated with previous epidemics of 1978, 1984, and 1994. In fluoroquinolone-resistant strains, double mutations (Ser83-->Leu, Asp87-->Asn or Gly) and a single mutation (Ser80-->Ile) were detected in the QRDRs of gyrA and parC, respectively.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents / pharmacology*
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Asia, Southeastern
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DNA Gyrase / genetics*
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DNA Topoisomerase IV / genetics*
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Drug Resistance, Bacterial / genetics
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Dysentery, Bacillary / microbiology
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Fluoroquinolones / pharmacology
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Humans
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Microbial Sensitivity Tests
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Molecular Sequence Data
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Mutation
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Quinolones / pharmacology*
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Shigella dysenteriae / drug effects*
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Shigella dysenteriae / genetics*
Substances
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Anti-Bacterial Agents
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Fluoroquinolones
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Quinolones
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DNA Topoisomerase IV
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DNA Gyrase
Associated data
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GENBANK/AY692480
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GENBANK/AY692481
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GENBANK/AY692482
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GENBANK/AY692483
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GENBANK/AY692484
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GENBANK/AY695829
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GENBANK/AY695830
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GENBANK/AY695831
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GENBANK/AY695832
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GENBANK/AY776312
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GENBANK/AY776313
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GENBANK/AY776314
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GENBANK/AY776315
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GENBANK/AY776316
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GENBANK/AY776317
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GENBANK/AY776318
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GENBANK/AY776319
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GENBANK/AY776320
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GENBANK/AY776321
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GENBANK/AY776322
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GENBANK/AY776323
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GENBANK/AY776324
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GENBANK/AY776325