Osmotic stress responses of Streptococcus mutans UA159

FEMS Microbiol Lett. 2006 Feb;255(2):240-6. doi: 10.1111/j.1574-6968.2005.00076.x.

Abstract

The hyperosmotic stress response of Streptococcus mutans was investigated. Real-time reverse transcriptase-PCR and slot-blot analysis revealed that opuAA, opcA, Smu.2115, sodA and nox were induced after exposure to 0.4 M NaCl. Our data suggest that there is a cross-talk between osmotic and oxidative stress responses in S. mutans. Inactivation of Smu.2115, encoding a putative oxidoreductase, resulted in an acid-resistant and hydrogen peroxide-sensitive phenotype.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • ATP-Binding Cassette Transporters / genetics
  • ATP-Binding Cassette Transporters / metabolism
  • Bacterial Proteins / genetics
  • Bacterial Proteins / metabolism*
  • Biofilms / growth & development
  • Gene Deletion
  • Gene Expression Regulation, Bacterial*
  • Heat-Shock Response*
  • Humans
  • Osmotic Pressure
  • Oxidative Stress
  • Oxidoreductases / genetics
  • Oxidoreductases / metabolism
  • Reverse Transcriptase Polymerase Chain Reaction
  • Sodium Chloride / pharmacology*
  • Streptococcus mutans / genetics
  • Streptococcus mutans / growth & development
  • Streptococcus mutans / metabolism
  • Streptococcus mutans / physiology*

Substances

  • ATP-Binding Cassette Transporters
  • Bacterial Proteins
  • Sodium Chloride
  • Oxidoreductases