Effects of normobaric interval hypoxic training (NIH) on blood aggregation (BA) were studied in 22 male subjects (19 to 50 y.o.) given three types of treatment courses with hypoxic mixtures of nitrogen and 10 % oxygen (HGM10): short (5-7 sessions of six 5-min HGM10 cycles with 5-min intervals for breathing air), standard (10 sessions with the six HGM10 cycles), and extended (15 sessions with six 7-min HGM10 cycles alternating with 3-min air breathing). The standard and extended treatment courses did not lead to the positive BA dynamics and were characterized by asynchronous jumping of the rheologic and coagulolithic potentials. The standard course produced moderate synchronous dynamics of the biochemical and biophysical BA modules at fairly high and essentially equal rheologic and coagulolithic potentials and, therefore, proved to be best for normal males. NIH was recommended for treatment and prophylaxis in aviation medicine as an advanced method to facilitate accommodation to harsh occupational environments.