Pulmonary Embolism (PE) has a wide clinical spectrum. It is imperative to detect patients with a high risk to develop right ventricular failure, because this is the main cause of death in patients with massive PE. In this group of patients, invasive therapies to relieve pulmonary obstruction and right ventricle overload should be used as soon as possible. We report a 85 years old male with massive PE treated with pharmacological thrombolysis and mechanical fragmentation with an angioplasty balloon. Pulmonary perfusion improved significantly. Afterwards, systemic anticoagulation was started and an inferior vena cava filter was installed percutaneously. The patient was discharged in good conditions, five days after admission.