Rapid generation of molecular complexity using "hybrid" multi-component reactions (MCRs): application to the synthesis of alpha-amino nitriles and 1,2-diamines

Chem Commun (Camb). 2006 Feb 14:(6):649-51. doi: 10.1039/b516192d. Epub 2006 Jan 6.

Abstract

Methyleneaziridines can be converted into a wide range of 1,2-diamines and 2-cyanopiperidines in a single operation with the formation of three intermolecular carbon-carbon bonds using a "hybrid" MCR.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aziridines / chemistry
  • Carbon / chemistry
  • Combinatorial Chemistry Techniques
  • Cyanides / chemistry*
  • Cyclization
  • Diamines / chemical synthesis*
  • Methane / analogs & derivatives
  • Models, Chemical
  • Molecular Structure
  • Nitriles / chemical synthesis*
  • Piperidines / chemical synthesis*

Substances

  • Aziridines
  • Cyanides
  • Diamines
  • Nitriles
  • Piperidines
  • Carbon
  • Methane