Water extracts of Prunella vulgaris and P. laciniata have been investigated for their immunomodulatory and antiinflammatory activities concerning their effect on the mitogenic response of murine splenocytes and nitric oxide production by murine peritoneal macrophages in vitro. It was found that both extracts stimulated the proliferation of T-lymphocytes and suppressed NO production in lipopolysaccharide-stimulated macrophages dose dependently without any cytotoxicity.
Copyright 2006 John Wiley & Sons, Ltd.