Abstract
One new (1) and four known (2-5) ursene triterpenes with potent inhibition of the formation of the bacterial biofilm Pseudomonas aeruginosa PA01 were obtained from Diospyros dendo using a high-throughput natural products chemistry procedure. These compounds were isolated as mass-limited samples. The miniaturization of the structure elucidation and dereplication was performed primarily utilizing a capillary-scale NMR probe.
Publication types
-
Research Support, N.I.H., Extramural
MeSH terms
-
Biofilms / drug effects*
-
Biofilms / growth & development
-
Diospyros / chemistry*
-
Magnetic Resonance Spectroscopy
-
Molecular Structure
-
Plant Leaves / chemistry
-
Pseudomonas aeruginosa / drug effects*
-
Pseudomonas aeruginosa / growth & development
-
Triterpenes / chemistry
-
Triterpenes / isolation & purification*
-
Triterpenes / pharmacology
Substances
-
3-O-cis-p-coumaroyl-20-hydroxy-12-ursen-28-oic acid
-
Triterpenes