Influence of HBcAg in liver cell plasma on expression of transforming growth factor-beta 1 in liver tissue of low-grade chronic hepatitis B patients

World J Gastroenterol. 2006 Jan 7;12(1):127-9. doi: 10.3748/wjg.v12.i1.127.

Abstract

Aim: To study the influence of HBcAg on the expression of transforming growth factor-beta 1 (TGF-beta1) in liver tissue of low-grade chronic hepatitis B (CHB) patients.

Methods: The expression of TGF-beta1 and HBcAg in liver samples from 93 low-grade CHB patients was detected by immunohistochemistry and valuated by semi-quantitative scoring.

Results: In the 93 low-grade CHB patients, HBcAg was expressed in cell plasma but not in the liver tissue. There was no significant difference between the two groups.

Conclusion: The expression of TGF-beta1 is not related with HBcAg expressed as plasma type in the tissues of low-grade CHB patients.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Female
  • Hepatitis B Core Antigens / analysis*
  • Hepatitis C, Chronic / metabolism*
  • Humans
  • Immunohistochemistry
  • Liver / chemistry*
  • Male
  • Middle Aged
  • Transforming Growth Factor beta / analysis*
  • Transforming Growth Factor beta1

Substances

  • Hepatitis B Core Antigens
  • TGFB1 protein, human
  • Transforming Growth Factor beta
  • Transforming Growth Factor beta1