Stereoselective synthesis of the western hemisphere of salinomycin

Org Lett. 2006 Feb 2;8(3):527-30. doi: 10.1021/ol052900w.

Abstract

[structure: see text]. A convergent and module-based strategy for the asymmetric synthesis of the western hemisphere (C1-C17 fragment) of salinomycin has been devised. This new synthetic approach relies on highly stereoselective C-glycosidation and aldol processes.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aldehydes / chemistry
  • Anti-Bacterial Agents / chemical synthesis*
  • Anti-Bacterial Agents / chemistry
  • Ionophores
  • Molecular Structure
  • Pyrans / chemical synthesis*
  • Pyrans / chemistry
  • Stereoisomerism

Substances

  • Aldehydes
  • Anti-Bacterial Agents
  • Ionophores
  • Pyrans
  • salinomycin
  • 3-hydroxybutanal