Synthesis and antifungal activity of 6-hydroxycinnolines

Chung-Kyu Ryu; Jung Yoon Lee

doi:10.1016/j.bmcl.2006.01.005

Synthesis and antifungal activity of 6-hydroxycinnolines

Bioorg Med Chem Lett. 2006 Apr 1;16(7):1850-3. doi: 10.1016/j.bmcl.2006.01.005. Epub 2006 Jan 24.

Authors

Chung-Kyu Ryu¹, Jung Yoon Lee

Affiliation

¹ College of Pharmacy, Ewha Womans University, Seodaemun-ku, Seoul 120-750, Republic of Korea. ckryu@mm.ewha.ac.kr

PMID: 16434193
DOI: 10.1016/j.bmcl.2006.01.005

Abstract

6-Hydroxycinnolines 2 and cyclohexa-2,5-diene-1,4-dione derivatives 6 were synthesized and tested for in vitro antifungal activity against Candida and Aspergillus species. 6-Hydroxycinnolines 2 showed, in general, more potent antifungal activity against Candida species than the other cyclohexa-2,5-diene-1,4-diones. The results suggest that 6-hydroxycinnolines would be potent antifungal agents.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antifungal Agents / chemical synthesis*
Antifungal Agents / chemistry
Antifungal Agents / pharmacology*
Aspergillus / drug effects
Candida / drug effects
Heterocyclic Compounds, 2-Ring / chemical synthesis*
Heterocyclic Compounds, 2-Ring / chemistry
Heterocyclic Compounds, 2-Ring / pharmacology*
Molecular Structure

Substances

Antifungal Agents
Heterocyclic Compounds, 2-Ring
cinnoline