A new phenanthrene with a spirolactone from Dendrobium chrysanthum and its anti-inflammatory activities

Bioorg Med Chem. 2006 May 15;14(10):3496-501. doi: 10.1016/j.bmc.2006.01.004. Epub 2006 Jan 23.

Abstract

Investigation of phenolic patterns from the stems of Dendrobium chrysanthum by HPLC-PDA-MS has led to the isolation of a new phenanthrene derivative with a spirolactone ring, dendrochrysanene (1), that proved to suppress the mRNA level of TNF-alpha, IL8, IL10, and iNOS in murine peritoneal macrophages. The structure of 1 was characterized on the basis of various NMR (1H, 13C, 1H-1H COSY, HMQC, and HMBC), mass spectrometry, and X-ray crystal diffraction data.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anti-Inflammatory Agents / chemistry
  • Anti-Inflammatory Agents / pharmacology
  • Cells, Cultured
  • Crystallography, X-Ray
  • Dendrobium / chemistry*
  • Drugs, Chinese Herbal / chemistry
  • Interleukins / metabolism
  • Macrophages, Peritoneal / drug effects
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Phenanthrenes / chemistry*
  • Phenanthrenes / metabolism
  • Phenanthrenes / pharmacology*
  • Spiro Compounds / chemistry*
  • Spiro Compounds / metabolism
  • Spiro Compounds / pharmacology*
  • Spironolactone / chemistry*
  • Tumor Necrosis Factors / metabolism

Substances

  • Anti-Inflammatory Agents
  • Drugs, Chinese Herbal
  • Interleukins
  • Phenanthrenes
  • Spiro Compounds
  • Tumor Necrosis Factors
  • dendrochrysanene
  • Spironolactone